mspipeline

This list gives a bit more detail about the phase 3 trials in progress. Typically, if there is an announcement of a drug successfully completing a trial, I will move it to the next stage before I see a press release or report saying that a new trial is starting. I assume it will move to the next stage. The only exception is for small (20-100 participants) phase 2 trials, as drugs don’t seem to move to phase 3 until they have completed a placebo-controlled phase 2 trial with well over 100 participants.

[updated April 18, 2009]

Phase III Trials

1. BG12 (Biogen)

http://www.clinicaltrials.gov/ct/show/NCT00420212

http://www.clinicaltrials.gov/ct/show/NCT00451451

2. Campath (aka alemtuzumab) (Genzyme)

http://www.genzyme.com/corp/media/GENZ%20PR-050207.asp

3. Cannabinoids – oral (PPMS) (Clinical Neurology Research Group – Plymouth)

http://www.pms.ac.uk/cnrg/cupid.php

4. FTY720 (aka fingolimod) (2 trials: RRMS and PPMS) (Novartis)

http://www.clinicaltrials.gov/ct/show/NCT00355134

http://www.clinicaltrials.gov/ct/show/NCT00289978

http://www.clinicaltrials.gov/ct/show/NCT00340834

http://www.clinicaltrials.gov/ct2/show/NCT00731692

5. Interferon beta 1a – PEGylated (bi-weekly or monthly injection) (Biogen Idec)

http://library.corporate-ir.net/library/14/148/148682/items/323432/703556BC-623A-424B-81E5-8236B14E0A21_BIIBQ408Slides.pdf

http://seekingalpha.com/article/119054-biogen-idec-q4-2008-earnings-call-transcript?page=4

6. Laquinimod (aka ABR-215062) (Teva)

http://www.tevapharm.com/pr/2007/pr_668.asp

7. MBP8298 (aka Dirucotide) (BioMS) (trial for SPMS)

http://www.biomsmedical.com/clinical-trials-maestro-01.php

http://www.clinicaltrials.gov/ct/show/NCT00468611

8. Minocycline (MS Society of Canada, MS Scientific Research Foundation)

http://www.msanswers.ca/QuestionView.aspx?L=2&QID=636

9. MN-166 (aka ibudilast and Ketas) (Medicinova)

http://www.medicinova.com/html/research_multiplesclerosis.html

http://investors.medicinova.com/releasedetail.cfm?ReleaseID=235413

http://www.primenewswire.com/newsroom/news.html?d=139633

10. Mycophenolate mofetil (aka Cellcept) (with Avonex)

http://www.clinicaltrials.gov/ct/show/NCT00324506

11. Mylinax (oral cladribine) (Merck Serono)

http://www.clinicaltrials.gov/ct/show/NCT00213135

http://www.clinicaltrials.gov/ct/show/NCT00436826

12. Progestin and Estradiol (Hospices Civils de Lyon)

http://www.clinicaltrials.gov/ct/show/NCT00127075

13. Revimmune (aka high-dose cyclophosphamide or cytoxan) (trial for refractory MS) (Accentia Biopharmaceuticals)

http://www.reuters.com/article/pressRelease/idUS260988+14-Aug-2008+BW20080814

14. Stem cells – autologous hematopoietic (ASTIMS trial)

http://www.astims.org/

15. T-Cell Vaccination (aka TCV-01-002) (Sheba Medical Center)

http://www.clinicaltrials.gov/ct/show/NCT00228228

16. Teriflunomide (aka HMR 1726) (Sanofi-Aventis)

http://www.clinicaltrials.gov/ct/show/NCT00134563

17. Trimesta (oral) (estriol) (with copaxone) (Adeona Pharmaceuticals)

http://www.adeonapharma.com/pipeline.php?pageID=8

http://www.clinicaltrials.gov/ct/show/NCT00451204

This list gives a bit more detail about the phase 1 trials in progress. Typically, if there is an announcement of a drug successfully completing a trial, I will move it to the next stage before I see a press release or report saying that a new trial is starting. I assume it will move to the next stage.

[updated May 3, 2009]

Phase I Trials

1. Amiloride (0xford University)

http://news.bbc.co.uk/2/hi/health/7086911.stm

2. AZD5904 (AstraZeneca)

http://www.astrazeneca.com/article/511390.aspx

3. BaroFeron (BaroFold)

http://www.pharmaceutical-business-review.com/article_news.asp?guid=A1C1119D-174D-4BB5-AAC8-DCD60C51657B

4. BCX-4208 (aka DADMe-Immunicillin-H or R3421) (BioCryst and Roche)

http://www.biocryst.com/bcx_4208.htm

5. BGC20-0134 (BTG)

http://www.btgplc.com/BTGPipeline/233/BGC200134.html

6. Cannabinor (Pharmos)

http://www.pharmoscorp.com/development/cannabinor.html

7. CCX140 (CCR2 antagonist) (ChemoCentryx)

http://www.chemocentryx.com/product/CCR2.html

http://www.chemocentryx.com/product/overview.html

8. CS-0777 (Daiichi-Sankyo)

http://clinicaltrials.gov/show/NCT00616733

9. Extracorporeal photochemotherapy (University of Milano-Bicocca)

http://www.springerlink.com/content/a3722uqnq355n4n4/

10. Far Infrared Irradiation (GAAD Medical Research Institute, Canada)

http://www.clinicaltrials.gov/ct2/show/NCT00674934

11. GRC 4039 (Glenmark Pharmaceuticals)

http://www.glenmarkpharma.com/research/clinical.html

12. INCB8696 (Incyte)

http://www.incyte.com/drugs_product_pipeline.html

13. Linoleic Acid (omega-6) (University of Rochester)

http://www.clinicaltrials.gov/ct2/show/NCT00638196

14. Lipoic acid (Oregon Health and Science University)

http://www.ohsu.edu/xd/research/centers-institutes/neurology/multiple-sclerosis-center/research/index.cfm

http://www.clinicaltrials.gov/ct2/show/NCT00676156

http://www.researchcrossroads.org/index.php?view=article&id=50%3Agrant-details&option=com_content&Itemid=64&grant_id=3794469

15. Low Fat Diet (Oregon Health and Science University)

http://www.clinicaltrials.gov/ct2/show/NCT00852722

16. Mesenchymal stem cell transplantation (autologous) (Cleveland Clinic)

http://www.clinicaltrials.gov/ct2/show/NCT00813969

17. MLN0415 (Millenium / Sanofi-Aventis)

http://www.mlnm.com/rd/inflammation/candidates/mln0415.asp

18. MM-093 (Recombinant Human Alpha-Fetoprotein) (Merrimack)

http://www.merrimackpharma.com/pipeline/index.html

19. NI-0401 (NovImmune)

http://www.novimmune.com/press/com20060626.php

20. ONO-4641 (oral S1P receptor agonist) (Ono Pharmaceutical)

http://www.ono.co.jp/jp/ir_info/annual/pdf/2008/fi0804.pdf

21. PI-2301 (Peptimmune)

http://www.peptimmune.com/pipeline/

22. Prolactin (Stem Cell Therapeutics / U of Calgary)

http://www.stemcellnetwork.ca/projects.php

http://www.stemcellthera.com/pdf/SCT3Q08MD_A.pdf

http://cnrp.marketwire.com/cnrp_files/20080707-707sss.pdf

http://cnrp.marketwire.com/cnrp_files/20090409-409SSS1.pdf

23. R1295 (Roche)

http://www.roche.com/research_and_development/pipeline/roche_pharma_pipeline.htm

24. R3477 (Roche / Actelion)

http://www.roche.com/research_and_development/pipeline/roche_pharma_pipeline.htm

http://www.actelion.com/uninet/www/www_main_p.nsf/Content/S1P1+Receptor+Agonist+in+Clinical+Development

25. RTL1000 (Artielle ImmunoTherapeutics)

http://www.clinicaltrials.gov/ct/show/NCT00411723

26. SC12267 (4SC AG)

http://www.4sc.de/en/index.php?csrc=http://www.4sc.de/en/news/releases/07_04_26_eng_Studienhalbzeit.htm

http://www.dvcg.de/gb/news/portfolio_presse.asp?artikel=504

27. Sildenafil Citrate (aka Viagra)

http://clinicaltrials.gov/ct/show/NCT00094068

28. TBC-4746 (Encysive Pharmaceuticals / Pfizer)

http://www.encysive.com/products.html

29. TK54 (LTKfarma)

http://www.genopole.org/media/pdf/eng/annuaire/entreprises/ltk-farma-en.pdf

http://www.prnewswire.co.uk/cgi/news/release?id=174816

30. Valomaciclovir (EPB-348) (Epiphany Biosciences)

http://www.epiphanybio.com/news/Press_Release_23MAR09.pdf

http://www.epiphanybio.com/pipe/index.html

This list gives a bit more detail about the phase 2 trials in progress. Typically, if there is an announcement of a drug successfully completing a trial, I will move it to the next stage before I see a press release or report saying that a new trial is starting. I assume it will move to the next stage. The only exception is for small (20-100 participants) phase 2 trials, as drugs don’t seem to move to phase 3 until they have completed a placebo-controlled phase 2 trial with well over 100 participants.

[updated June 26, 2009]

Phase II Trials

1. Alferon N Injection (Hemispherx Biopharma)

http://www.hemispherx.net/content/rnd/product_candidates.htm

2. Atacicept (aka TACI-Ig) (Merck Serono and ZymoGenetics)

http://www.merckserono.net/en/merck_serono/how_we_innovate/pipeline/pipeline.jsp#0

3. ATL/TV 1102 (Antisense Therapeutics / Teva)

http://www.tevapharm.com/pr/2008/pr_768.asp

http://www.antisense.com.au/_116.asp

4. ATX-MS1467 (Apitope Technology / Merck Serono)

http://www.apitope.com/apitopepressrele.html

http://www.apitope.com/apitopepressrelf.html

http://www.apitope.com/apitopepressreld.html

5. Autologous hematopoietic stem cell transplantation (2 trials: HALT MS and Northwestern University)

http://www.clinicaltrials.gov/ct2/show/NCT00288626

http://www.clinicaltrials.gov/ct2/show/NCT00273364

6. Bacille Calmette-Guèrin (BCG) Vaccine

http://www.clinicaltrials.gov/ct/show/NCT00202410

7. BAF312 (Novartis)

http://www.clinicaltrials.gov/ct2/show/NCT00879658

8. BHT-3009-01 (aka DNA vaccine) (Bayhill Therapeutics) (with Lipitor)

http://www.bayhilltherapeutics.com/PressRelease_18.html

http://www.clinicaltrials.gov/ct/show/NCT00382629

http://www.clinicaltrials.gov/ct/show/NCT00103974

9. CDP323 (UCB / Biogen)

http://www.clinicaltrials.gov/ct/show/NCT00484536

10. Chaperonin 10 (aka Cpn10 or XToll) (C-Bio)

http://msj.sagepub.com/cgi/content/abstract/15/3/329

11. Daclizumab (aka Zenapax) (Protein Design Labs, Biogen-Idec)

http://www.clinicaltrials.gov/ct/show/NCT00390221

12. Doxycycline (with Avonex)

http://www.clinicaltrials.gov/ct/show/NCT00246324

http://www.ncbi.nlm.nih.gov/pubmed/18071030

13. EGCg (Epigallocatechin-Gallate) (Charite University, Berlin)

http://www.clinicaltrials.gov/ct/show/NCT00525668

http://www.clinicaltrials.gov/ct2/show/NCT00836719

14. Enkorten (aka FAR404) (Farmacija)

http://www.farmacija.co.ba/enkorten.htm

http://www.farmacija.co.ba/riddiagram.htm

http://www.farmacija.co.ba/ridfar.htm

15. Erythropoietin (aka EPO) (Stem Cell Therapeutics)

http://www.clinicaltrials.gov/ct/show/NCT00355095

16. ESP (an analogue of a metabolite of azathioprine) (Biomolecular Pharma / Mount Allison University)

http://www.biomolecularpharma.com/MSMV_Paper.pdf

17. Estroprogestins (with IFN beta 1a) (S. Andrea Hospital)

http://www.clinicaltrials.gov/ct/show/NCT00151801

18. Firategrast (aka SB-683699 and T-0047) (oral) (Glaxosmithkline / Tanabe)

http://www.clinicaltrials.gov/ct/show/NCT00395317

19. Fluoxetine (aka Prozac) (SP, PP & RRMS) (University Medical Center Groningen)

http://www.controlled-trials.com/ISRCTN38456328

20. Flupirtine (Bayer Schering)

http://clinicaltrials.gov/show/NCT00623415

21. GEM-SP (SPMS) (Gemacbio)

http://www.biolsci.org/v04p0150.htm

http://www.ncbi.nlm.nih.gov/pubmed/19548873

22. Helminth-induced immunomodulation therapy (HINT) (U of Wisconsin)

http://www.clinicaltrials.gov/ct2/show/NCT00645749

23. Hookworm (WIRMS – Worms for Immune Regulation in MS) (UK) (RRMS)

http://www.mssociety.org.uk/research/research_we_fund/research_funding/spring_2008/grant_885.html

24. HP184 (aka nerispirdine) (Sanofi-Aventis)

http://en.sanofi-aventis.com/research_innovation/rd_key_figures/rd_key_figures.asp

25. Interferon alpha (oral) (University of Texas-Houston)

http://www.ncbi.nlm.nih.gov/pubmed/16542137

http://neurology.uth.tmc.edu/faculty/bio-Staley-Brod.html

26. Kynurenine (aka Tranilast, Rizoben, 3,4-DAA) (Nuon Therapeutics)

http://www.nuontherapeutics.com/products/

27. Lipitor (aka atorvastatin) (Pfizer)

http://www.clinicaltrials.gov/ct/show/NCT00094172

http://www.clinicaltrials.gov/ct/show/NCT00137176

28. Low-dose naltrexone (aka LDN)

http://www.lowdosenaltrexone.org/ldn_trials.htm

29. LY2127399 (Anti-BAFF Human Antibody) (Eli Lilly)

http://www.clinicaltrials.gov/ct2/show/NCT00882999

30. Lymphocytapheresis, azathioprine & prednisone (SPMS) (U of Chicago)

http://www.nationalmssociety.org/research/clinical-trials/index.aspx

(see “Clinical Trials in MS” .pdf document on the above page)

31. LymphoStat-B (belimumab) (Human Genome Sciences, Glaxosmithkline)

http://www.hgsi.com/latest/human-genome-sciences-reports-progress-with-late-stage-products-and-new-initia-2.html

32. Masitinib (SPMS and PPMS) (aka Kinavet or AB1010) (AB Science)

http://www.ambosmedios.com/ebooknews/investment_2008-11-24_digest.pdf (page 47)

http://www.abstracts2view.com/aan2009seattle/view.php?nu=AAN09L_P06.130

33. MBP8298 (aka Dirucotide) (BioMS) (RRMS trial)

http://www.biomsmedical.com/mindset_01.asp

http://www.biomsmedical.com/display-press-release.php?id=185

34. Mesenchymal Stem Cells (2 trials: University of Cambridge and Hadassah Medical Organization)

http://www.clinicaltrials.gov/ct/show/NCT00395200

http://www.clinicaltrials.gov/ct2/show/NCT00781872

35. Methotrexate – intrathecal

http://www.msrcny.org/pdfs/Current_Research_Projects_2006.pdf

http://www.neura.net/mylibrary/print.asp?src=1&id=494

36. Minocycline (3 trials: by itself, with copaxone, with rebif)

http://www.clinicaltrials.gov/ct/show/NCT00381459

http://www.ncbi.nlm.nih.gov/pubmed/17463074

http://www.abstracts2view.com/aan2007boston/view.php?nu=AAN07L_S02.003

37. Ocrelizumab (R1594) (Roche/Genentech/Biogen)

http://www.roche.com/research_and_development/pipeline/roche_pharma_pipeline.htm

38. Ofatumumab (HuMax-CD20) (Genmab)

http://www.genmab.com/ScienceAndResearch/ProductsinDevelopment.aspx

39. Omega-3 fatty acid

http://www.nature.com/ncpneuro/journal/v5/n2/full/ncpneuro1009.html#B18

40. Pixantrone (aka BBR 2778 ) (Cell Therapeutics)

http://www.nationalmssociety.org/research/clinical-trials/index.aspx

(”Clinical Trials in MS…” .pdf document)

41. Pravastatin (Nantes University Hospital – France)

http://www.clinicaltrials.gov/ct/show/NCT00200655

42. RG2077 (aka CTLA4-IgG4m) (Immune Tolerance Network and Repligen)

http://clinicaltrials.gov/ct/show/NCT00076934

http://www.ncbi.nlm.nih.gov/pubmed/18794494

http://www.immunetolerance.org/sites/files/downloads/ITN_2007_Research_Report_web.pdf (page 25)

43. Riluzole (with Avonex) (UCSF)

http://neurology.ucsf.edu/msc/research.htm#riluzole

44. RPI-78M (Nutra Pharma / ReceptoPharm)

http://www.receptopharm.com/drug_development/pipeline.php

45. Stem cell transplant from donor (not autologous) (University of Louisville)

http://www.clinicaltrials.gov/ct2/show/NCT00497952

46. Testosterone (UCLA)

http://www.ncbi.nlm.nih.gov/pubmed/17502467

http://www.nationalmssociety.org/site/PageServer?pagename=HOM_RES_research_2006apr4

47. Tovaxin (Opexa)

http://www.clinicaltrials.gov/ct/show/NCT00245622

48. Treosulfan (SPMS) (University of Wuerzburg, Germany)

http://www.ncbi.nlm.nih.gov/pubmed/17446994

49. Vitamin D3 (with calcium) (St. Michael’s Hospital – Toronto)

http://www.direct-ms.org/plannedresearch.html

http://www.ncbi.nlm.nih.gov/pubmed/17823429

50. Zocor (aka simvastatin) (RRMS and SPMS) (Merck Serono)

http://www.clinicaltrials.gov/ct/show/NCT00242268

http://www.clinicaltrials.gov/ct/show/NCT00146068

http://www.clinicaltrials.gov/ct/show/NCT00429442

http://www.mssociety.org.uk/research/take_part_in_research/simvastatin.html