This list gives a bit more detail about the phase 2 trials in progress. Typically, if there is an announcement of a drug successfully completing a trial, I will move it to the next stage before I see a press release or report saying that a new trial is starting. I assume it will move to the next stage. The only exception is for small (20-100 participants) phase 2 trials, as drugs don’t seem to move to phase 3 until they have completed a placebo-controlled phase 2 trial with well over 100 participants.
[updated June 26, 2009]
Phase II Trials
1. Alferon N Injection (Hemispherx Biopharma)
http://www.hemispherx.net/content/rnd/product_candidates.htm
2. Atacicept (aka TACI-Ig) (Merck Serono and ZymoGenetics)
http://www.merckserono.net/en/merck_serono/how_we_innovate/pipeline/pipeline.jsp#0
3. ATL/TV 1102 (Antisense Therapeutics / Teva)
http://www.tevapharm.com/pr/2008/pr_768.asp
http://www.antisense.com.au/_116.asp
4. ATX-MS1467 (Apitope Technology / Merck Serono)
http://www.apitope.com/apitopepressrele.html
http://www.apitope.com/apitopepressrelf.html
http://www.apitope.com/apitopepressreld.html
5. Autologous hematopoietic stem cell transplantation (2 trials: HALT MS and Northwestern University)
http://www.clinicaltrials.gov/ct2/show/NCT00288626
http://www.clinicaltrials.gov/ct2/show/NCT00273364
6. Bacille Calmette-Guèrin (BCG) Vaccine
http://www.clinicaltrials.gov/ct/show/NCT00202410
7. BAF312 (Novartis)
http://www.clinicaltrials.gov/ct2/show/NCT00879658
8. BHT-3009-01 (aka DNA vaccine) (Bayhill Therapeutics) (with Lipitor)
http://www.bayhilltherapeutics.com/PressRelease_18.html
http://www.clinicaltrials.gov/ct/show/NCT00382629
http://www.clinicaltrials.gov/ct/show/NCT00103974
9. CDP323 (UCB / Biogen)
http://www.clinicaltrials.gov/ct/show/NCT00484536
10. Chaperonin 10 (aka Cpn10 or XToll) (C-Bio)
http://msj.sagepub.com/cgi/content/abstract/15/3/329
11. Daclizumab (aka Zenapax) (Protein Design Labs, Biogen-Idec)
http://www.clinicaltrials.gov/ct/show/NCT00390221
12. Doxycycline (with Avonex)
http://www.clinicaltrials.gov/ct/show/NCT00246324
http://www.ncbi.nlm.nih.gov/pubmed/18071030
13. EGCg (Epigallocatechin-Gallate) (Charite University, Berlin)
http://www.clinicaltrials.gov/ct/show/NCT00525668
http://www.clinicaltrials.gov/ct2/show/NCT00836719
14. Enkorten (aka FAR404) (Farmacija)
http://www.farmacija.co.ba/enkorten.htm
http://www.farmacija.co.ba/riddiagram.htm
http://www.farmacija.co.ba/ridfar.htm
15. Erythropoietin (aka EPO) (Stem Cell Therapeutics)
http://www.clinicaltrials.gov/ct/show/NCT00355095
16. ESP (an analogue of a metabolite of azathioprine) (Biomolecular Pharma / Mount Allison University)
http://www.biomolecularpharma.com/MSMV_Paper.pdf
17. Estroprogestins (with IFN beta 1a) (S. Andrea Hospital)
http://www.clinicaltrials.gov/ct/show/NCT00151801
18. Firategrast (aka SB-683699 and T-0047) (oral) (Glaxosmithkline / Tanabe)
http://www.clinicaltrials.gov/ct/show/NCT00395317
19. Fluoxetine (aka Prozac) (SP, PP & RRMS) (University Medical Center Groningen)
http://www.controlled-trials.com/ISRCTN38456328
20. Flupirtine (Bayer Schering)
http://clinicaltrials.gov/show/NCT00623415
21. GEM-SP (SPMS) (Gemacbio)
http://www.biolsci.org/v04p0150.htm
http://www.ncbi.nlm.nih.gov/pubmed/19548873
22. Helminth-induced immunomodulation therapy (HINT) (U of Wisconsin)
http://www.clinicaltrials.gov/ct2/show/NCT00645749
23. Hookworm (WIRMS – Worms for Immune Regulation in MS) (UK) (RRMS)
http://www.mssociety.org.uk/research/research_we_fund/research_funding/spring_2008/grant_885.html
24. HP184 (aka nerispirdine) (Sanofi-Aventis)
http://en.sanofi-aventis.com/research_innovation/rd_key_figures/rd_key_figures.asp
25. Interferon alpha (oral) (University of Texas-Houston)
http://www.ncbi.nlm.nih.gov/pubmed/16542137
http://neurology.uth.tmc.edu/faculty/bio-Staley-Brod.html
26. Kynurenine (aka Tranilast, Rizoben, 3,4-DAA) (Nuon Therapeutics)
http://www.nuontherapeutics.com/products/
27. Lipitor (aka atorvastatin) (Pfizer)
http://www.clinicaltrials.gov/ct/show/NCT00094172
http://www.clinicaltrials.gov/ct/show/NCT00137176
28. Low-dose naltrexone (aka LDN)
http://www.lowdosenaltrexone.org/ldn_trials.htm
29. LY2127399 (Anti-BAFF Human Antibody) (Eli Lilly)
http://www.clinicaltrials.gov/ct2/show/NCT00882999
30. Lymphocytapheresis, azathioprine & prednisone (SPMS) (U of Chicago)
http://www.nationalmssociety.org/research/clinical-trials/index.aspx
(see “Clinical Trials in MS” .pdf document on the above page)
31. LymphoStat-B (belimumab) (Human Genome Sciences, Glaxosmithkline)
32. Masitinib (SPMS and PPMS) (aka Kinavet or AB1010) (AB Science)
http://www.ambosmedios.com/ebooknews/investment_2008-11-24_digest.pdf (page 47)
http://www.abstracts2view.com/aan2009seattle/view.php?nu=AAN09L_P06.130
33. MBP8298 (aka Dirucotide) (BioMS) (RRMS trial)
http://www.biomsmedical.com/mindset_01.asp
http://www.biomsmedical.com/display-press-release.php?id=185
34. Mesenchymal Stem Cells (2 trials: University of Cambridge and Hadassah Medical Organization)
http://www.clinicaltrials.gov/ct/show/NCT00395200
http://www.clinicaltrials.gov/ct2/show/NCT00781872
35. Methotrexate – intrathecal
http://www.msrcny.org/pdfs/Current_Research_Projects_2006.pdf
http://www.neura.net/mylibrary/print.asp?src=1&id=494
36. Minocycline (3 trials: by itself, with copaxone, with rebif)
http://www.clinicaltrials.gov/ct/show/NCT00381459
http://www.ncbi.nlm.nih.gov/pubmed/17463074
http://www.abstracts2view.com/aan2007boston/view.php?nu=AAN07L_S02.003
37. Ocrelizumab (R1594) (Roche/Genentech/Biogen)
http://www.roche.com/research_and_development/pipeline/roche_pharma_pipeline.htm
38. Ofatumumab (HuMax-CD20) (Genmab)
http://www.genmab.com/ScienceAndResearch/ProductsinDevelopment.aspx
39. Omega-3 fatty acid
http://www.nature.com/ncpneuro/journal/v5/n2/full/ncpneuro1009.html#B18
40. Pixantrone (aka BBR 2778 ) (Cell Therapeutics)
http://www.nationalmssociety.org/research/clinical-trials/index.aspx
(”Clinical Trials in MS…” .pdf document)
41. Pravastatin (Nantes University Hospital – France)
http://www.clinicaltrials.gov/ct/show/NCT00200655
42. RG2077 (aka CTLA4-IgG4m) (Immune Tolerance Network and Repligen)
http://clinicaltrials.gov/ct/show/NCT00076934
http://www.ncbi.nlm.nih.gov/pubmed/18794494
http://www.immunetolerance.org/sites/files/downloads/ITN_2007_Research_Report_web.pdf (page 25)
43. Riluzole (with Avonex) (UCSF)
http://neurology.ucsf.edu/msc/research.htm#riluzole
44. RPI-78M (Nutra Pharma / ReceptoPharm)
http://www.receptopharm.com/drug_development/pipeline.php
45. Stem cell transplant from donor (not autologous) (University of Louisville)
http://www.clinicaltrials.gov/ct2/show/NCT00497952
46. Testosterone (UCLA)
http://www.ncbi.nlm.nih.gov/pubmed/17502467
http://www.nationalmssociety.org/site/PageServer?pagename=HOM_RES_research_2006apr4
47. Tovaxin (Opexa)
http://www.clinicaltrials.gov/ct/show/NCT00245622
48. Treosulfan (SPMS) (University of Wuerzburg, Germany)
http://www.ncbi.nlm.nih.gov/pubmed/17446994
49. Vitamin D3 (with calcium) (St. Michael’s Hospital – Toronto)
http://www.direct-ms.org/plannedresearch.html
http://www.ncbi.nlm.nih.gov/pubmed/17823429
50. Zocor (aka simvastatin) (RRMS and SPMS) (Merck Serono)
http://www.clinicaltrials.gov/ct/show/NCT00242268
http://www.clinicaltrials.gov/ct/show/NCT00146068
http://www.clinicaltrials.gov/ct/show/NCT00429442
http://www.mssociety.org.uk/research/take_part_in_research/simvastatin.html
