This list gives a bit more detail about the phase 3 trials in progress. Typically, if there is an announcement of a drug successfully completing a trial, I will move it to the next stage before I see a press release or report saying that a new trial is starting. I assume it will move to the next stage. The only exception is for small (20-100 participants) phase 2 trials, as drugs don’t seem to move to phase 3 until they have completed a placebo-controlled phase 2 trial with well over 100 participants.
[updated August 12, 2009]
Phase III Trials
1. BG12 (Biogen)
http://www.clinicaltrials.gov/ct/show/NCT00420212
http://www.clinicaltrials.gov/ct/show/NCT00451451
2. Campath (aka alemtuzumab) (Genzyme)
http://www.genzyme.com/corp/media/GENZ%20PR-050207.asp
3. Cannabinoids – oral (PPMS) (Clinical Neurology Research Group – Plymouth)
http://www.pms.ac.uk/cnrg/cupid.php
4. Daclizumab (aka Zenapax) (Protein Design Labs, Biogen-Idec)
http://investors.facetbiotech.com/phoenix.zhtml?c=224496&p=irol-newsArticle&ID=1316064&highlight=
http://www.clinicaltrials.gov/ct/show/NCT00390221
5. FTY720 (aka fingolimod) (2 trials: RRMS and PPMS) (Novartis)
http://www.clinicaltrials.gov/ct/show/NCT00355134
http://www.clinicaltrials.gov/ct/show/NCT00289978
http://www.clinicaltrials.gov/ct/show/NCT00340834
http://www.clinicaltrials.gov/ct2/show/NCT00731692
6. Interferon beta 1a – PEGylated (bi-weekly or monthly injection) (Biogen Idec)
http://seekingalpha.com/article/119054-biogen-idec-q4-2008-earnings-call-transcript?page=4
7. Laquinimod (aka ABR-215062) (Teva)
http://www.tevapharm.com/pr/2007/pr_668.asp
8. Minocycline (MS Society of Canada, MS Scientific Research Foundation)
http://www.msanswers.ca/QuestionView.aspx?L=2&QID=636
9. MN-166 (aka ibudilast and Ketas) (Medicinova)
http://www.medicinova.com/html/research_multiplesclerosis.html
http://investors.medicinova.com/releasedetail.cfm?ReleaseID=235413
http://www.primenewswire.com/newsroom/news.html?d=139633
10. Mycophenolate mofetil (aka Cellcept) (with Avonex)
http://www.clinicaltrials.gov/ct/show/NCT00324506
11. Mylinax (oral cladribine) (Merck Serono)
http://www.clinicaltrials.gov/ct/show/NCT00213135
http://www.clinicaltrials.gov/ct/show/NCT00436826
12. Progestin and Estradiol (Hospices Civils de Lyon)
http://www.clinicaltrials.gov/ct/show/NCT00127075
13. Revimmune (aka high-dose cyclophosphamide or cytoxan) (trial for refractory MS) (Accentia Biopharmaceuticals)
http://www.reuters.com/article/pressRelease/idUS260988+14-Aug-2008+BW20080814
14. Stem cells – autologous hematopoietic (ASTIMS trial)
15. T-Cell Vaccination (aka TCV-01-002) (Sheba Medical Center)
http://www.clinicaltrials.gov/ct/show/NCT00228228
16. Teriflunomide (aka HMR 1726) (Sanofi-Aventis)
http://www.clinicaltrials.gov/ct/show/NCT00134563
17. Trimesta (oral) (estriol) (with copaxone) (Adeona Pharmaceuticals)
http://www.adeonapharma.com/pipeline.php?pageID=8
http://www.clinicaltrials.gov/ct/show/NCT00451204
