This list gives a bit more detail about the phase 2 trials in progress. Typically, if there is an announcement of a drug successfully completing a trial, I will move it to the next stage before I see a press release or report saying that a new trial is starting. I assume it will move to the next stage. The only exception is for small (20-100 participants) phase 2 trials, as drugs don’t seem to move to phase 3 until they have completed a placebo-controlled phase 2 trial with well over 100 participants.

[updated October 9, 2009]

Phase II Trials

1. Alferon N Injection (Hemispherx Biopharma)

http://www.hemispherx.net/content/rnd/product_candidates.htm

2. ATL/TV 1102 (Antisense Therapeutics / Teva)

http://www.tevapharm.com/pr/2008/pr_768.asp

http://www.antisense.com.au/_116.asp

3. ATX-MS1467 (Apitope Technology / Merck Serono)

http://www.apitope.com/apitopepressrele.html

http://www.apitope.com/apitopepressrelf.html

http://www.apitope.com/apitopepressreld.html

4. Autologous hematopoietic stem cell transplantation (2 trials: HALT MS and Northwestern University)

http://www.clinicaltrials.gov/ct2/show/NCT00288626

http://www.clinicaltrials.gov/ct2/show/NCT00273364

5. Bacille Calmette-Guèrin (BCG) Vaccine

http://www.clinicaltrials.gov/ct/show/NCT00202410

6. BAF312 (Novartis)

http://www.clinicaltrials.gov/ct2/show/NCT00879658

7. BHT-3009-01 (aka DNA vaccine) (Bayhill Therapeutics) (with Lipitor)

http://www.bayhilltherapeutics.com/PressRelease_18.html

http://www.clinicaltrials.gov/ct/show/NCT00382629

http://www.clinicaltrials.gov/ct/show/NCT00103974

8. Chaperonin 10 (aka Cpn10 or XToll) (C-Bio)

http://msj.sagepub.com/cgi/content/abstract/15/3/329

9. Doxycycline (with Avonex)

http://www.clinicaltrials.gov/ct/show/NCT00246324

http://www.ncbi.nlm.nih.gov/pubmed/18071030

10. EGCg (Epigallocatechin-Gallate) (Charite University, Berlin)

http://www.clinicaltrials.gov/ct/show/NCT00525668

http://www.clinicaltrials.gov/ct2/show/NCT00836719

11. Enkorten (aka FAR404) (Farmacija)

http://www.farmacija.co.ba/enkorten.htm

http://www.farmacija.co.ba/riddiagram.htm

http://www.farmacija.co.ba/ridfar.htm

12. Erythropoietin (aka EPO) (Stem Cell Therapeutics)

http://www.clinicaltrials.gov/ct/show/NCT00355095

13. ESP (an analogue of a metabolite of azathioprine) (Biomolecular Pharma / Mount Allison University)

http://www.biomolecularpharma.com/MSMV_Paper.pdf

14. Estroprogestins (with IFN beta 1a) (S. Andrea Hospital)

http://www.clinicaltrials.gov/ct/show/NCT00151801

15. Firategrast (aka SB-683699 and T-0047) (oral) (Glaxosmithkline / Tanabe)

http://www.clinicaltrials.gov/ct/show/NCT00395317

16. Fluoxetine (aka Prozac) (SP, PP & RRMS) (University Medical Center Groningen)

http://www.controlled-trials.com/ISRCTN38456328

17. Flupirtine (Bayer Schering)

http://clinicaltrials.gov/show/NCT00623415

18. GEM-SP (SPMS) (Gemacbio)

http://www.biolsci.org/v04p0150.htm

http://www.ncbi.nlm.nih.gov/pubmed/19548873

19. Helminth-induced immunomodulation therapy (HINT) (U of Wisconsin)

http://www.clinicaltrials.gov/ct2/show/NCT00645749

20. Hookworm (WIRMS – Worms for Immune Regulation in MS) (UK) (RRMS)

http://www.mssociety.org.uk/research/research_we_fund/research_funding/spring_2008/grant_885.html

21. HP184 (aka nerispirdine) (Sanofi-Aventis)

http://en.sanofi-aventis.com/research_innovation/rd_key_figures/rd_key_figures.asp

22. Interferon alpha (oral) (University of Texas-Houston)

http://www.ncbi.nlm.nih.gov/pubmed/16542137

http://neurology.uth.tmc.edu/faculty/bio-Staley-Brod.html

23. Kynurenine (aka Tranilast, Rizoben, 3,4-DAA) (Nuon Therapeutics)

http://www.nuontherapeutics.com/products/

24. Lipitor (aka atorvastatin) (Pfizer)

http://www.clinicaltrials.gov/ct/show/NCT00094172

http://www.clinicaltrials.gov/ct/show/NCT00137176

25. Low-dose naltrexone (aka LDN)

http://www.lowdosenaltrexone.org/ldn_trials.htm

26. LY2127399 (Anti-BAFF Human Antibody) (Eli Lilly)

http://www.clinicaltrials.gov/ct2/show/NCT00882999

27. Lymphocytapheresis, azathioprine & prednisone (SPMS) (U of Chicago)

http://www.nationalmssociety.org/research/clinical-trials/index.aspx

(see “Clinical Trials in MS” .pdf document on the above page)

28. LymphoStat-B (belimumab) (Human Genome Sciences, Glaxosmithkline)

http://www.hgsi.com/latest/human-genome-sciences-reports-progress-with-late-stage-products-and-new-initia-2.html

29. Masitinib (SPMS and PPMS) (aka Kinavet or AB1010) (AB Science)

http://www.ambosmedios.com/ebooknews/investment_2008-11-24_digest.pdf (page 47)

http://www.abstracts2view.com/aan2009seattle/view.php?nu=AAN09L_P06.130

30. Mesenchymal Stem Cells (2 trials: University of Cambridge and Hadassah Medical Organization)

http://www.clinicaltrials.gov/ct/show/NCT00395200

http://www.clinicaltrials.gov/ct2/show/NCT00781872

31. Methotrexate – intrathecal

http://www.msrcny.org/pdfs/Current_Research_Projects_2006.pdf

http://www.neura.net/mylibrary/print.asp?src=1&id=494

32. Minocycline (3 trials: by itself, with copaxone, with rebif)

http://www.clinicaltrials.gov/ct/show/NCT00381459

http://www.ncbi.nlm.nih.gov/pubmed/17463074

http://www.abstracts2view.com/aan2007boston/view.php?nu=AAN07L_S02.003

33. Ocrelizumab (R1594) (Roche/Genentech/Biogen)

http://www.roche.com/research_and_development/pipeline/roche_pharma_pipeline.htm

34. Ofatumumab (HuMax-CD20) (Genmab)

http://www.genmab.com/ScienceAndResearch/ProductsinDevelopment.aspx

35. Omega-3 fatty acid

http://www.nature.com/ncpneuro/journal/v5/n2/full/ncpneuro1009.html#B18

36. PI-2301 (Peptimmune)

http://www.peptimmune.com/pipeline/

http://sev.prnewswire.com/health-care-hospitals/20090825/NE6587725082009-1.html

37. Pixantrone (aka BBR 2778 ) (Cell Therapeutics)

http://www.nationalmssociety.org/research/clinical-trials/index.aspx

(“Clinical Trials in MS…” .pdf document)

38. Pravastatin (Nantes University Hospital – France)

http://www.clinicaltrials.gov/ct/show/NCT00200655

39. RG3477 (aka ACT-128800) (Roche / Actelion)

http://www1.actelion.com/en/our-company/news-and-events/index.page?newsId=1346473

http://www.roche.com/research_and_development/pipeline/roche_pharma_pipeline.htm

http://www.actelion.com/uninet/www/www_main_p.nsf/Content/S1P1+Receptor+Agonist+in+Clinical+Development

40. RG2077 (aka CTLA4-IgG4m) (Immune Tolerance Network and Repligen)

http://clinicaltrials.gov/ct/show/NCT00076934

http://www.ncbi.nlm.nih.gov/pubmed/18794494

http://www.immunetolerance.org/sites/files/downloads/ITN_2007_Research_Report_web.pdf (page 25)

41. Riluzole (with Avonex) (UCSF)

http://neurology.ucsf.edu/msc/research.htm#riluzole

42. RPI-78M (Nutra Pharma / ReceptoPharm)

http://www.receptopharm.com/drug_development/pipeline.php

43. RTL1000 (Artielle ImmunoTherapeutics)

http://www.reuters.com/article/pressRelease/idUS98713+14-Sep-2009+PRN20090914

http://www.clinicaltrials.gov/ct/show/NCT00411723

44. Stem cell transplant from donor (not autologous) (University of Louisville)

http://www.clinicaltrials.gov/ct2/show/NCT00497952

45. Testosterone (UCLA)

http://www.ncbi.nlm.nih.gov/pubmed/17502467

http://www.nationalmssociety.org/site/PageServer?pagename=HOM_RES_research_2006apr4

46. Tovaxin (Opexa)

http://www.clinicaltrials.gov/ct/show/NCT00245622

47. Treosulfan (SPMS) (University of Wuerzburg, Germany)

http://www.ncbi.nlm.nih.gov/pubmed/17446994

48. Vitamin D3 (with calcium) (St. Michael’s Hospital – Toronto)

http://www.direct-ms.org/plannedresearch.html

http://www.ncbi.nlm.nih.gov/pubmed/17823429

49. Zocor (aka simvastatin) (RRMS and SPMS) (Merck Serono)

http://www.clinicaltrials.gov/ct/show/NCT00242268

http://www.clinicaltrials.gov/ct/show/NCT00146068

http://www.clinicaltrials.gov/ct/show/NCT00429442

http://www.mssociety.org.uk/research/take_part_in_research/simvastatin.html