I have been waiting for this one for a long time. ShK-186 has entered phase 1, in the Netherlands.
ShK-186 inhibits the Kv1.3 potassium ion channel. Kineta’s program is the first Kv1.3-specific inhibitor advanced into the clinic. Kv1.3 has been a target of industry efforts for its role in instigating activation of effector memory T-cells, which are major mediators of autoimmune disease. Kineta scientific advisor and University of California, Irvine Professor, K. George Chandy and his collaborators invented ShK-186 by modifying natural sea anemone-derived peptide inhibitors of Kv1.3. ShK-186 can reduce disease symptoms and pathology in animal models of MS without broadly suppressing the immune system.