Archive for phase 2

Phase 2

This list gives a bit more detail about the phase 2 trials in progress. Typically, if there is an announcement of a drug successfully completing a trial, I will move it to the next stage before I see a press release or report saying that a new trial is starting. I assume it will move to the next stage. The only exception is for small (20-100 participants) phase 2 trials, as drugs don’t seem to move to phase 3 until they have completed a placebo-controlled phase 2 trial with well over 100 participants.

[updated May 12, 2013]

Phase II Trials

1. Abatacept (National Institute of Allergy and Infectious Diseases)

2. ACT-128800 (aka ponesimod) (Actelion)

3. AIN457 (aka secukinumab) (Novartis)

4. Alferon N Injection (Hemispherx Biopharma)

5. Amiloride (Oxford University) (trial for primary progressive patients)

6. ATL/TV 1102 (Antisense Therapeutics / Teva)!upload_files%5Cattachment%5CAntisense%20Web%20Report.pdf

7. Autologous hematopoietic stem cell transplantation (HALT MS)

8. Bacille Calmette-Guèrin (BCG) Vaccine

9. BAF312 (Novartis)

10. BHT-3009-01 (aka DNA vaccine) (Bayhill Therapeutics)

11. Chronic cerebrospinal venous insufficiency (CCSVI) treatment

12. E2007 (Eisai)

13. EGCg (Epigallocatechin-Gallate)

14. Enkorten (aka FAR404) (Farmacija)

15. Erythropoietin (aka EPO) (Institut fuer anwendungsorientierte Forschung und klinische Studien gGmbH)

16. ESP (an analogue of a metabolite of azathioprine) (Biomolecular Pharma / Mount Allison University)

17. Estroprogestins (with IFN beta 1a) (S. Andrea Hospital)

18. Firategrast (aka SB-683699 and T-0047) (oral) (Glaxosmithkline / Tanabe)

19. Fluoxetine (aka Prozac) (SP, PP & RRMS) (University Medical Center Groningen)

20. Flupirtine (Bayer Schering)

21. GEM-SP (SPMS) (Gemac Pharma);jsessionid=1qsghncm1oelj.alexandra

22. GNbAC1 (Monoclonal antibody against MSRV/HERV-W) (GeNeuro)

23. Helminth-induced immunomodulation therapy (3 studies: University of Wisconsin, Rigshospitalet, Denmark, Charite University)

24. Hookworm (WIRMS – Worms for Immune Regulation in MS) (UK) (RRMS)

25. Hydroxyurea (PPMS) (S. Andrea Hospital)

26. Idebenone (National Institute of Neurological Disorders and Stroke)

27. Interferon alpha (oral) (University of Texas-Houston)

28. Lamotrigine (with Interferon Beta 1a) (Cantonal Hospital of St. Gallen, Switzerland)

29. Lipitor (aka atorvastatin) (Pfizer)–sms041410.php

30. Lithium (US Department of Veterans Affairs)

31. LY2127399 (Anti-BAFF Human Antibody) (Eli Lilly)

32. Melatonin (Tehran University of Medical Sciences)

33. Mesenchymal Stem Cells (four phase II trials listed at, plus 1 in the UK)

34. Methotrexate – intrathecal

35. Minocycline

36. MIS416 (trial for progressive MS) (Innate Therapeutics)

37. Mycophenolate mofetil (aka Cellcept) (with Avonex)

38. Myelin Peptides (epicutaneous immunisation) (Medical University of Lodz, Poland)

39. MyeloXen (Xenetic Biosciences and Pharmsynthez)

40. NeuroVax (Immune Response BioPharma)

41. NT-KO-003 (Advancell and Neurotec Pharma)

42. Ofatumumab (HuMax-CD20) (Genmab and Glaxosmithkline)

43. Olesoxime (TRO19622) (Trophos)

44. Omega-3 fatty acids (University of Washington)

45. ONO-4641 (oral S1P receptor agonist) (Ono Pharmaceutical)

46. Phenytoin (University College, London)

47. PI-2301 (Merck Serono)

48. Pixantrone (aka BBR 2778 ) (Cell Therapeutics)

(“Clinical Trials in MS…” .pdf document)

49. Raltegravir (Isentress) (Queen Mary University of London)

50. Riluzole (with Avonex) (UCSF)

51. RPI-78M (Nutra Pharma / ReceptoPharm)

52. RTL1000 (Artielle ImmunoTherapeutics)

53. Stem cell transplant from donor (allogeneic) (Duke University)

54. Tovaxin (aka Tcelna) (Opexa)

55. Trimesta (oral) (estriol) (with copaxone) (Adeona Pharmaceuticals)

56. Vitamin D3 (Johns Hopkins University, Carmel Medical Center, Merck, Charite University, University of Turku)

57. Zocor (aka simvastatin) (RRMS and SPMS) (Merck Serono)

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