This list gives a bit more detail about the phase 2 trials in progress. Typically, if there is an announcement of a drug successfully completing a trial, I will move it to the next stage before I see a press release or report saying that a new trial is starting. I assume it will move to the next stage. The only exception is for small (20-100 participants) phase 2 trials, as drugs don’t seem to move to phase 3 until they have completed a placebo-controlled phase 2 trial with well over 100 participants.
[updated May 12, 2013]
Phase II Trials
1. Abatacept (National Institute of Allergy and Infectious Diseases)
http://clinicaltrials.gov/show/NCT01116427
2. ACT-128800 (aka ponesimod) (Actelion)
http://www1.actelion.com/sites/en/scientists/development-pipeline/phase-2/ponesimod.page
3. AIN457 (aka secukinumab) (Novartis)
http://www.clinicaltrials.gov/ct2/show/NCT01051817
4. Alferon N Injection (Hemispherx Biopharma)
http://www.hemispherx.net/content/rnd/product_candidates.htm
5. Amiloride (Oxford University) (trial for primary progressive patients)
http://www.mssociety.org.uk/ms-news-and-research/ms-research/research-projects/cure#ACTION
http://news.bbc.co.uk/2/hi/health/7086911.stm
http://brain.oxfordjournals.org/content/134/2/571.long
6. ATL/TV 1102 (Antisense Therapeutics / Teva)
http://www.tevapharm.com/en-US/Media/News/Pages/2009/1555769.aspx
www.antisense.com.au/!upload_files%5Cattachment%5CAntisense%20Web%20Report.pdf
http://www.antisense.com.au/_116.asp
7. Autologous hematopoietic stem cell transplantation (HALT MS)
http://www.clinicaltrials.gov/ct2/show/NCT00288626
8. Bacille Calmette-Guèrin (BCG) Vaccine
http://www.clinicaltrials.gov/ct/show/NCT00202410
9. BAF312 (Novartis)
http://www.clinicaltrials.gov/ct2/show/NCT00879658
http://www.clinicaltrials.gov/ct2/show/NCT01185821
http://www.novartis.com/innovation/research-development/clinical-pipeline/index.shtml
10. BHT-3009-01 (aka DNA vaccine) (Bayhill Therapeutics)
http://www.bayhilltx.com/BHT-3009.html
http://www.bayhilltx.com/PressReleases.html
11. Chronic cerebrospinal venous insufficiency (CCSVI) treatment
http://www.clinicaltrials.gov/ct2/show/NCT01264848
http://www.clinicaltrials.gov/ct2/show/NCT01371760
http://www.clinicaltrials.gov/ct2/show/NCT01201707
http://www.clinicaltrials.gov/ct2/show/NCT01205633
http://www.clinicaltrials.gov/ct2/show/NCT01089686
http://www.ctv.ca/generic/WebSpecials/pdf/YMVA_4198_Zamboni_final.pdf
http://www.ncbi.nlm.nih.gov/pubmed/20018140
12. E2007 (Eisai)
http://www.eisai.com/research/index.html
13. EGCg (Epigallocatechin-Gallate)
http://www.clinicaltrials.gov/ct2/show/NCT01417312
http://www.clinicaltrials.gov/ct2/show/NCT01451723
http://www.clinicaltrials.gov/ct2/show/NCT00799890
http://www.clinicaltrials.gov/ct/show/NCT00525668
http://www.clinicaltrials.gov/ct2/show/NCT00836719
14. Enkorten (aka FAR404) (Farmacija)
http://www.farmacija.co.ba/eng/multipla.htm
http://www.farmacija.co.ba/eng/download/v4Mehmedika-Suljic%20Bangkok%202009.pdf
http://www.farmacija.co.ba/eng/download/v4Alajbegovic%20Bangkok%202009.pdf
15. Erythropoietin (aka EPO) (Institut fuer anwendungsorientierte Forschung und klinische Studien gGmbH)
http://www.clinicaltrials.gov/ct/show/NCT00355095
16. ESP (an analogue of a metabolite of azathioprine) (Biomolecular Pharma / Mount Allison University)
http://www.biomolecularpharma.com/MSMV_Paper.pdf
http://www.biomolecularpharma.com/ms_drug.php
17. Estroprogestins (with IFN beta 1a) (S. Andrea Hospital)
http://www.clinicaltrials.gov/ct/show/NCT00151801
18. Firategrast (aka SB-683699 and T-0047) (oral) (Glaxosmithkline / Tanabe)
http://www.clinicaltrials.gov/ct/show/NCT00395317
http://www.mt-pharma.co.jp/shared/show.php?url=../e/develop/pipeline/index.html
19. Fluoxetine (aka Prozac) (SP, PP & RRMS) (University Medical Center Groningen)
http://www.controlled-trials.com/ISRCTN38456328
http://dissertations.ub.rug.nl/faculties/medicine/2009/j.p.mostert/?pLanguage=en&pFullItemRecord=ON
http://www.ncbi.nlm.nih.gov/pubmed/20178822
20. Flupirtine (Bayer Schering)
http://clinicaltrials.gov/show/NCT00623415
21. GEM-SP (SPMS) (Gemac Pharma)
http://www.gemacpharma.com/node/47
http://www.biolsci.org/v04p0150.htm
http://www.ncbi.nlm.nih.gov/pubmed/19548873
22. GNbAC1 (Monoclonal antibody against MSRV/HERV-W) (GeNeuro)
http://www.clinicaltherapeutics.com/article/S0149-2918%2812%2900649-2/abstract
http://www.geneuro.com/en/technologies/pipeline.php
23. Helminth-induced immunomodulation therapy (3 studies: University of Wisconsin, Rigshospitalet, Denmark, Charite University)
http://www.clinicaltrials.gov/ct2/show/NCT01413243
http://www.clinicaltrials.gov/ct2/show/NCT00645749
http://www.clinicaltrials.gov/ct2/show/NCT01006941
24. Hookworm (WIRMS – Worms for Immune Regulation in MS) (UK) (RRMS)
http://www.clinicaltrials.gov/ct2/show/NCT01470521
http://www.mssociety.org.uk/node/521080
25. Hydroxyurea (PPMS) (S. Andrea Hospital)
http://clinicaltrials.gov/ct2/show/NCT01103583
26. Idebenone (National Institute of Neurological Disorders and Stroke)
http://www.clinicaltrials.gov/ct2/show/NCT00950248
27. Interferon alpha (oral) (University of Texas-Houston)
http://www.mdpi.com/1424-8247/3/4/1108/pdf
http://www.ncbi.nlm.nih.gov/pubmed/16542137
http://neurology.uth.tmc.edu/faculty/bio-Staley-Brod.html
28. Lamotrigine (with Interferon Beta 1a) (Cantonal Hospital of St. Gallen, Switzerland)
http://clinicaltrials.gov/show/NCT00917839
29. Lipitor (aka atorvastatin) (Pfizer)
http://www.clinicaltrials.gov/ct2/show/NCT00818103
http://www.clinicaltrials.gov/ct2/show/NCT01111656
http://www.eurekalert.org/pub_releases/2010-04/uoc–sms041410.php
30. Lithium (US Department of Veterans Affairs)
http://www.clinicaltrials.gov/ct2/show/NCT01259388
31. LY2127399 (Anti-BAFF Human Antibody) (Eli Lilly)
http://www.clinicaltrials.gov/ct2/show/NCT00882999
32. Melatonin (Tehran University of Medical Sciences)
http://clinicaltrials.gov/show/NCT01279876
33. Mesenchymal Stem Cells (four phase II trials listed at clinicaltrials.gov, plus 1 in the UK)
http://www.clinicaltrials.gov/ct/show/NCT00395200
http://www.clinicaltrials.gov/ct2/show/NCT00781872
http://www.clinicaltrials.gov/ct2/show/NCT01056471
http://www.clinicaltrials.gov/ct2/show/NCT01228266
http://www.mssociety.org.uk/ms-news/2011/07/ms-society-funds-major-international-stem-cell-research
34. Methotrexate – intrathecal
http://www.ncbi.nlm.nih.gov/pubmed/20532907
http://www.neura.net/mylibrary/print.asp?src=1&id=494
35. Minocycline
http://www.clinicaltrials.gov/ct2/show/NCT01073813
http://www.abstracts2view.com/aan2007boston/view.php?nu=AAN07L_S02.003
36. MIS416 (trial for progressive MS) (Innate Therapeutics)
http://www.innateimmunotherapeutics.com/clinical-trials
37. Mycophenolate mofetil (aka Cellcept) (with Avonex)
http://www.clinicaltrials.gov/ct/show/NCT00324506
38. Myelin Peptides (epicutaneous immunisation) (Medical University of Lodz, Poland)
39. MyeloXen (Xenetic Biosciences and Pharmsynthez)
http://en.pharmsynthez.com/Myeloxen.66.html
http://www.xeneticbio.com/uploads/xeneticmakesclinicalprogress.pdf
40. NeuroVax (Immune Response BioPharma)
http://www.immuneresponsebiopharma.com/Pages/DrugDiscovery.aspx
41. NT-KO-003 (Advancell and Neurotec Pharma)
42. Ofatumumab (HuMax-CD20) (Genmab and Glaxosmithkline)
http://www.clinicaltrials.gov/ct2/show/NCT00640328
http://www.clinicaltrials.gov/ct2/show/NCT01457924
http://www.gsk.com/media/pressreleases/2010/2010_pressrelease_10098.htm
43. Olesoxime (TRO19622) (Trophos)
http://www.trophos.com/research/pipeline.htm
http://www.trophos.com/news/pr20111025.htm
44. Omega-3 fatty acids (University of Washington)
http://www.clinicaltrials.gov/ct2/show/NCT01026272
http://www.nature.com/ncpneuro/journal/v5/n2/full/ncpneuro1009.html#B18
45. ONO-4641 (oral S1P receptor agonist) (Ono Pharmaceutical)
www.ono.co.jp/eng/news/pdf/sm_cn120417.pdf
http://www.clinicaltrials.gov/ct2/show/NCT01226745
http://www.clinicaltrials.gov/ct2/show/NCT01081782
http://www.ono.co.jp/jp/ir_info/annual/pdf/2009/fi0911.pdf
46. Phenytoin (University College, London)
http://clinicaltrials.gov/ct2/show/NCT01451593
47. PI-2301 (Merck Serono)
www.merckserono.com/corp.merckserono_2011/en/images/20110916_en_tcm1494_80349.pdf?Version=
http://www.ncbi.nlm.nih.gov/pubmed/20466440
48. Pixantrone (aka BBR 2778 ) (Cell Therapeutics)
http://www.nationalmssociety.org/research/clinical-trials/index.aspx
(“Clinical Trials in MS…” .pdf document)
49. Raltegravir (Isentress) (Queen Mary University of London)
http://clinicaltrials.gov/show/NCT01767701
http://multiple-sclerosis-research.blogspot.co.uk/2013/03/research-day-talk-charcot-project.html
50. Riluzole (with Avonex) (UCSF)
http://neurology.ucsf.edu/msc/research.htm#riluzole
http://www.clinicaltrials.gov/ct2/show/NCT00501943
51. RPI-78M (Nutra Pharma / ReceptoPharm)
http://www.receptopharm.com/drug_development/pipeline.php
52. RTL1000 (Artielle ImmunoTherapeutics)
http://www.reuters.com/article/pressRelease/idUS98713+14-Sep-2009+PRN20090914
http://www.artielle.com/drug-development/multiple-sclerosis.php
http://www.clinicaltrials.gov/ct/show/NCT00411723
53. Stem cell transplant from donor (allogeneic) (Duke University)
http://www.clinicaltrials.gov/ct2/show/NCT00849745
54. Tovaxin (aka Tcelna) (Opexa)
http://www.opexatherapeutics.com/?page=release§ion=news&article=110411
http://www.opexatherapeutics.com/?page=release§ion=news&article=091410
http://www.opexatherapeutics.com/?page=release§ion=news&article=080510
55. Trimesta (oral) (estriol) (with copaxone) (Adeona Pharmaceuticals)
http://www.adeonapharma.com/pipeline.php?pageID=8
http://www.clinicaltrials.gov/ct/show/NCT00451204
56. Vitamin D3 (Johns Hopkins University, Carmel Medical Center, Merck, Charite University, University of Turku)
http://www.vitamindcouncil.org/clinical-trials-testing-vitamin-ds-effect-on-ms/
http://www.ncbi.nlm.nih.gov/pubmed/21620416
http://www.ncbi.nlm.nih.gov/pubmed/17823429
http://www.vitamindandms.org/clinicaltrial/clinicaltrial.html
http://www.clinicaltrials.gov/ct2/show/NCT01490502
http://www.clinicaltrials.gov/ct2/show/NCT01005095
http://www.clinicaltrials.gov/ct2/show/NCT01024777
http://www.clinicaltrials.gov/ct2/show/NCT01198132
http://www.clinicaltrials.gov/ct2/show/NCT01440062
http://www.clinicaltrials.gov/ct2/show/NCT01339676
http://www.clinicaltrials.gov/ct2/show/NCT01285401
57. Zocor (aka simvastatin) (RRMS and SPMS) (Merck Serono)
http://www.clinicaltrials.gov/ct/show/NCT00242268
http://www.clinicaltrials.gov/ct/show/NCT00429442
http://www.clinicaltrials.gov/ct2/show/NCT00647348
