Archive for phase 3

Phase 3

This list gives a bit more detail about the phase 3 trials in progress. Typically, if there is an announcement of a drug successfully completing a trial, I will move it to the next stage before I see a press release or report saying that a new trial is starting. I assume it will move to the next stage. The only exception is for small (20-100 participants) phase 2 trials, as drugs don’t seem to move to phase 3 until they have completed a placebo-controlled phase 2 trial with well over 100 participants.

[updated April 6, 2013]

Phase III Trials

1. Autologous hematopoietic stem cell transplantation (aka Multiple Sclerosis International Stem Cell Transplant Trial)

http://www.clinicaltrials.gov/ct2/show/NCT00273364

2. Campath (aka alemtuzumab or Lemtrada) (Genzyme)

http://www.genzyme.com/research/pipeline/pipe_home.asp

http://www.clinicaltrials.gov/ct2/show/NCT00530348

http://www.clinicaltrials.gov/ct2/show/NCT00548405

http://www.clinicaltrials.gov/ct2/show/NCT00930553

http://www.clinicaltrials.gov/ct2/show/NCT01307332

http://www.clinicaltrials.gov/ct2/show/NCT01333358

http://www.clinicaltrials.gov/ct2/show/NCT01395316

3. Daclizumab (aka Zenapax) (Abbott, Biogen-Idec)

http://www.abbott.com/news-media/press-releases/2011-oct22.htm

http://www.biogenidec.com/research_product_pipeline.aspx?ID=5778

http://www.clinicaltrials.gov/ct2/show/NCT01064401

http://www.clinicaltrials.gov/ct/show/NCT00390221

http://www.clinicaltrials.gov/ct2/show/NCT01051349

http://www.clinicaltrials.gov/ct2/show/NCT00870740

http://www.clinicaltrials.gov/ct2/show/NCT01462318

4. Gilenya (aka fingolimod or FTY720) (PPMS) (Novartis)

http://www.clinicaltrials.gov/ct2/show/NCT00731692

5. Interferon beta 1a – PEGylated  (BIIB017) (bi-weekly or monthly injection) (Biogen Idec)

http://www.clinicaltrials.gov/ct2/show/NCT00906399

http://library.corporate-ir.net/library/14/148/148682/items/323432/703556BC-623A-424B-81E5-8236B14E0A21_BIIBQ408Slides.pdf

http://seekingalpha.com/article/119054-biogen-idec-q4-2008-earnings-call-transcript?page=4

6. Laquinimod (aka ABR-215062) (Teva)

http://www.tevapharm.com/en-US/Media/News/Pages/2011/1618694.aspx

http://www.clinicaltrials.gov/ct2/show/NCT00509145

http://www.clinicaltrials.gov/ct2/show/NCT00605215

http://www.clinicaltrials.gov/ct2/show/NCT00988052

http://www.clinicaltrials.gov/ct2/show/NCT01047319

7. Masitinib (SPMS and PPMS) (aka Kinavet or AB1010) (AB Science)

http://clinicaltrials.gov/ct2/show/NCT01433497

http://www.businesswire.com/news/home/20110906006398/en/AB-Science-announces-recruitment-patient-phase-3

http://www.abstracts2view.com/aan2009seattle/view.php?nu=AAN09L_P06.130

8. Minocycline (MS Society of Canada, MS Scientific Research Foundation)

http://www.clinicaltrials.gov/ct2/show/NCT00666887

http://www.msanswers.ca/QuestionView.aspx?L=2&QID=636

9. Ocrelizumab (R1594) (trials for PPMS and RRMS) (Genentech, Roche, Biogen)

http://www.roche.com/research_and_development/pipeline/roche_pharma_pipeline.htm

http://www.clinicaltrials.gov/ct2/show/NCT01194570

http://www.clinicaltrials.gov/ct2/show/NCT01412333

http://www.clinicaltrials.gov/ct2/show/NCT00676715

http://www.clinicaltrials.gov/ct2/show/NCT01247324

10. Progestin and Estradiol (Hospices Civils de Lyon)

http://www.clinicaltrials.gov/ct/show/NCT00127075

11. Revimmune (aka Cyrevia OR high-dose cyclophosphamide) (Accentia Biopharmaceuticals)

http://www.secinfo.com/d14D5a.qahnf.17.htm

http://www.accentia.net/science_revimmune.php

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