mspipeline

86 Comments »

1. 

   Scoobyjude said

   July 2, 2007 @ 6:51 pm

   Dignan, just wanted to say that when I was first dxed and was as low as I could get, your pipeline brought me out of it. It made me feel like there was really hope. For that I can’t thank you enough. Keep up the good work.

   Reply
2. 

   Lee said

   July 15, 2007 @ 3:09 pm

   I will read anything you write, Dignan…I’m in awe.

   Reply
3. 

   superman said

   July 24, 2007 @ 3:39 pm

   It sounds like some people are working for our recovery 😉
   We ought to them for believing in their coming final success.

   Reply
4. 

   anon said

   July 25, 2007 @ 6:02 pm

   You sir, have given me incredible hope that this is no longer an orphan disease. Thanks you so much for tracking this information, and keep up the good work!!!

   Reply
5. 

   Maz said

   October 2, 2007 @ 8:47 am

   Anyone has any news on Rituxan for PPMS? Is it a good sign that they’re still running the clinical trial?

   Reply
6. 

   Geoff said

   October 2, 2007 @ 7:09 pm

   Maz, it’s my understanding that the Rituxan for PPMS trial is due to finish in November. The companies expect to report results from the trial some time in the first half of 2008. I’m not entirely sure if that will mean Rituxan would be approved for use in PPMS, or whether another phase 3 trial might be required.

   Reply
7. 

   Daniel Drumm said

   December 12, 2007 @ 5:48 pm

   Your website is very well produced. Good work! I have RRMS.

   Reply
8. 

   Rita Masse said

   March 13, 2008 @ 4:06 am

   I am absolutely fascinated by how much is in various stages of research. Can you tell me, or do you know how I could find out what exactly is meant by each phase of research? How close or how far are we? Thanks much. I am a person with MS. Rita Masse
   100 Merrimack Ave. Unit 63
   Dracut, MA 01826
   (978) 454-3731
   ritaamasse@aol.com

   Reply
9. 

   Geoff said

   March 13, 2008 @ 9:07 pm

   Rita, good question. Here are a couple of good places for info on clinical trial phases:

   Wikipedia: http://en.wikipedia.org/wiki/Clinical_trial

   Multiple Sclerosis International Federation: http://www.msif.org/en/research/clinical_trials/ct_phases.html

   How close are we? If the results of the rituxan PPMS trial are good, they might apply for approval later in 2008. The first of the oral drugs in the final phase (phase 3) before approval could be approved and available in 2009. I can’t predict what drugs will be approved, but I’m pretty sure that starting in 2009, there will be at least one new drug approved to treat MS every single year until they find a cure. The current stage of MS research (that started with the approval of betaseron in the early 1990s) where we wait for years while the next candidate works it way through the trial process is going to end some time in the next 18 months.

   Reply
10. 

    Susie said

    April 26, 2008 @ 11:39 am

    What’s the news (if any) on Fampridine-SR? I want some!!!

    Reply
    • 

      ddietrich said

      August 7, 2009 @ 8:29 am

      The FDA is supposed to respond by April to Acorda’s submission for approval for Fampridine SR by October 2009. Another drug with a similar mechanism of action is in clinical trials for MS presently. Look at nerispirdine, under identifier NCT00811902 at clinicaltrials.gov.

      Reply
      • 

        Geoff said

        August 9, 2009 @ 1:32 pm

        ddietrich, thanks for the feedback. I really hope Fampridine and nerispirdine can be of use to people with MS.

        I decided not to track the symptomatic treatments in the pipeline. Tracking all of the symptomatic treatments that could be used for MS would be a big job in itself and I decided not to take it on.
11. 

    Geoff said

    April 27, 2008 @ 7:51 pm

    Susie,

    I haven’t really followed Fampridine very closely as I’m fixated on the disease-modifying treatments and not so much on the symptomatic treatments. It looks to me like Acorda expects to be finished their current phase 3 trial in 2008, but there are still several issues to clear up. See here (starting on p. 41):

    http://sec.edgar-online.com/2008/03/14/0001047469-08-002781/Section7.asp

    Reply
12. 

    Sally Adams said

    August 8, 2008 @ 4:31 pm

    I have been taking 17.5 mg of 4-AP (3 times daily) for 12 years. I have it compounded at Medicine Shoppe. It is one of 4 drugs that I cannot live without. Even though I am in a wheelchair, I know I would be unable to care for myself without this drug. I’ll be glad when it is approved, so my insurance company will cover it.

    Reply
13. 

    Meander said

    August 31, 2008 @ 1:16 pm

    Wow…this is some list. I will definitely have to come and read all this thoroughly. Thanks for putting out this information.

    http://www.healthcentral.com/multiple-sclerosis/c/73302/profile

    Reply
14. 

    Karen said

    December 3, 2008 @ 11:35 am

    Do you think that there will be a cure for this terrible disease one day? I try to be hopeful, but at 36, wonder is it too late to reap the benefits of any of these therapies?

    Reply
15. 

    Geoff said

    December 3, 2008 @ 12:27 pm

    Karen,
    I do think there will be a cure, and I don’t think it is too late for you to reap the benefits of the therapies in the pipeline.

    With all the drugs being investigated, and all the research on MS that is under way, and all the research into the immune system and the central nervous system that isn’t specific to MS, and all the research into genetics that isn’t specific to MS, and all the research into stem cells that isn’t specific to MS, and all the new imaging and testing technologies being developed, the scientific community will figure out MS. I obviously don’t know when, but I fully expect a cure in the next 20 years. I think people, even researchers in a specific area, often underestimate the impact that technological progress can have on our understanding.

    Geoff

    Reply
16. 

    Karen said

    December 3, 2008 @ 1:15 pm

    Thanks Geoff. I had a Dr. tell me recently that I would be in a wheelchair by Christmas and there was nothing else they could do for me. I appreciate your encouraging view. K.

    Reply
17. 

    Geoff said

    December 3, 2008 @ 8:00 pm

    Karen,
    I’m sorry to read what your doctor had to say. Have you ever checked out the ThisIsMS forums? I know there are a lot of MS patient forums online, but there are a lot of resourceful people who post there and who try all kinds of treatments. Maybe nothing miraculous, but if you want to leave no stone unturned…

    http://www.thisisms.com/forums.html

    Reply
18. 

    fran said

    December 28, 2008 @ 1:30 pm

    Have you heard anything of the work done at Henry Ford/Mount Alison? They have done a trial on 7 people (is that a phase I ? ), sounded incredibly promising.

    All I can find is the press release. Most frustrating!

    Reply
    • 

      Geoff said

      January 1, 2009 @ 10:20 pm

      Fran, I had seen the press release too, but didn’t find anything else, except this medical hypothesis article: http://www.biomolecularpharma.com/MSMV_Paper.pdf

      Since they are talking about the same thing (the MS associated measles virus), I assume the drug they discuss in the article is the same one the press release refers to: ESP, an analogue of a metabolite of azathioprine. This is also interesting because azathioprine has been used off-label as an MS treatment at least since the 1970s.

      I guess based on this news I will add the drug to the list in phase 2.

      Geoff

      Reply
19. 

    carlos hansen said

    February 13, 2009 @ 1:26 am

    Your site is very nice, very informative, it’s hopeful – I likey!

    Your last update was Jan 4, how often do you update? will we have a cure in our life time?

    Reply
20. 

    Geoff said

    February 13, 2009 @ 12:25 pm

    Carlos, thanks for the comment. I update the site any time I learn of new developments. Sometimes it’s updated multiple times in a week, sometimes not so much.

    Regarding the cure, obviously I’m just making a wild guess here, but I think we will have one within 20 years. Saying “have a cure” could mean a lot of things — e.g. discover the cause and feel confident we know what it will take to cure MS, or have a treatment that cures everybody in a phase 2 trial, so we think it’s a cure, but it’s not approved yet, or have a cure that is actually widely available to PwMS. When I say within 20 years, I’m hoping we will have the cure widely available within 20 years. Considering the clinical development of drugs is averaging around 8 years (varies widely though), that would mean I’m saying we’ll figure out MS within 10 years or so. I’m probably an optimist, but I think all the tools (imaging technology, computer simulations, large scale projects to define the proteome, connectome etc etc) are improving at such a rapid pace that we’re going to learn a surprising amount in the next 10 years. It won’t be like the last 10 years, we will acquire knowledge at a vastly great rate, and will have a better idea of how it all fits together.

    But keep in mind, I’m not a researcher, so it’s all just wild speculation.

    Geoff

    Reply
21. 

    Simon said

    March 27, 2009 @ 9:37 am

    Hi

    I do work in research, in cancer research at a large pharma.

    My wife has MS, but unfortunately I think its unrealistic to think of a “cure” in our lifetime. I’m 36.

    However, I do think that over the next 30-40 years we will see that MS becomes increasingly well managed both in terms of reducing disease severity in RRMS and in slowing disease progression in SPMS that it will become a manageable condition in the same way that people live and manage with diabetes, and more recently HIV.

    It is very rare for scientists to find an actual cure for a condition. But instead more common for a disease to become managed, both symptomatically and in terms of slowing progression.

    As our understanding of the physiology and molecular pathways that cause MS increases newer drugs will eventually become available which manage disease so well that in practical terms it will be as good as a cure because it will become more likely that someone just diagnosed with MS will die of heart disease or a stroke before their MS becomes too severe.

    Reply
22. 

    Geoff said

    March 28, 2009 @ 9:31 am

    Scott, thanks for your thoughts. As Yogi Berra said, it’s tough to make predictions, especially about the future.

    Having lots of smart people researching diseases with the technology we’ve had available for the last 40 or 50 years clearly hasn’t been enough to find cures for many diseases. If it was going to be more of the same for the next 40-50 years, I’d agree with you completely. But I am more optimistic about the amount of technological progress we will see over the next few decades and the influence that will have on medical research.

    Reply
23. 

    Simon said

    March 28, 2009 @ 11:43 am

    Hi Geoff

    yes that’s a good point about the technological tools available now.

    I think considering the huge investment put into drug research its probably true to say that science research has under-delivered over the last 25 years in terms of cures for diseases. You only have to look at cancer theraoy to see that it still largely depends on 1. chemotherapy and 2. surgery.

    When the human genome code was completed it was generally assumed this would lead to a big breakthrough in treatments, but it hasnt really happened yet. Part of the reason for this is to do with the lack of effort that was previously put into effective delivery systems for drugs. So the drug might have been very effecive once it reached its target, but in humans the delivery to that target was poor. But this is now being addressed by looking at ability of using viral and/or lipid delivery systems to effectively deliver drugs to their targets.

    So yes I think in many ways a big advance is really due. And perhaps we will see tihis happen now over the next decade.

    Reply
24. 

    Geoff said

    March 28, 2009 @ 2:47 pm

    I haven’t seen any stats on it, but I assume cancer research gets by far largest portion of the research dollar pie. I’m hoping that some of your cancer discoveries will also benefit other diseases, like MS, that have some immune system involvement, not to mention research into cancers of the central nervous system.

    Reply
25. 

    How to Get Six Pack Fast said

    April 15, 2009 @ 10:18 am

    My friend on Facebook shared this link and I’m not dissapointed that I came to your blog.

    Reply
26. 

    Fernando said

    April 20, 2009 @ 11:15 am

    Hi,

    Have been reading your post at thisisms (I’m in ms limbo right now).

    I don’t know if this drug fits here but it is somewhat related:

    Cethrin

    Cethrin for acute spinal cord injury:
    Miami Project neurosurgeon scientists are in negotiations with Alseres Pharmaceuticals, Inc. for the University of Miami to become an investigator site for a Phase 2 multicenter trial of a neuroprotective drug Cethrin. In preclinical studies, the drug has been shown to block an inhibitory injury mechanism that prevents axons from regrowing. A Phase 1 trial involving 27 patients with acute SCI has already been completed and suggests Cethrin is safe and well-tolerated. The data from this trial also suggests the treatment may improve a participant’s motor and sensory function. When the Phase 2 trial is approved by the FDA, The Miami Project will proceed with the trial once it receives University of Miami Institutional Review Board (IRB) approval.

    http://www.themiamiproject.org/Page.aspx?pid=339

    Sounds impressive but for SCI, why not for MS?
    I know, you’d have to have a separate list for “possible” drugs, but anyway, maybe we can keep an eye on this one.

    Thank you for your efforts keeping this site up to date, they are very much appreciated.

    Fernando

    Reply
27. 

    Fernando said

    April 20, 2009 @ 11:45 am

    There is a drug called BVA-101 that could fit in the pre-clinical section:

    http://www.thisisms.com/ftopict-7035-bva101.html

    Is there a reason for it not being in that section?

    If it is so, please forget this comment.

    Fernando

    Reply
28. 

    Geoff said

    April 20, 2009 @ 1:28 pm

    Fernando,

    Thanks for the information. I’m always glad to get tips. For a couple of reasons, I’m not going to add either drug. On BVA-101, it is preclinical, which I’ve given up tracking. I have some stats on the approval rate for drugs (in general, not MS-specific) that indicates that around 10-12% of all drugs that enter phase 1 go on to be approved one day. But of all the compounds tested in the preclinical stage, only around 10% ever even make it into clinical trials. So the odds are that around 1% of the drugs on the preclinical list will one day be treatments, and there aren’t even 100 drugs on the list…so after realizing the futility of it, I decided to give up. But I kept the preclinical section there, in case anybody is interested.

    On Cethrin, it does sound interesting, and it sounds like the kind of thing that could one day be used in MS, but in trying to decide what I would include on the list and what I wouldn’t, I arbitrarily decided to include drugs that aren’t in trials for MS at the moment, but where there is a recent statement from the drug sponsor saying they intend to begin MS trials soon (or something to that effect). For Cethrin, I don’t see any reference to one day testing on people with MS. If there is a statement like that out there, let me know and I’ll add it to the list right away.

    Thanks again for the info.

    Geoff

    Reply
29. 

    Fernando said

    April 22, 2009 @ 6:47 am

    Ok. You’re right.

    How do you keep track of everything? Do you use google alerts or something similar? Goggle alerts is a fine tool.

    Fernando

    Reply
30. 

    Geoff said

    April 22, 2009 @ 5:21 pm

    I don’t use Google alerts. I do use Google News, clinicaltrials.gov, the US MS Society’s list of clinical trials, Pubmed, conference abstracts from the major neurology/MS conferences and last but not least, tips I get, especially at ThisIsMS.com.

    Geoff

    Reply
31. 

    AL RPH said

    August 20, 2009 @ 2:10 pm

    I believe this article will be of interest to all.

    http://www.newswise.com/articles/view/555107/

    Reply
32. 

    Kreso said

    November 7, 2009 @ 2:53 pm

    Thank you for this list !!
    You have put an optimitisc smile on my face !

    Reply
33. 

    Janet Summers said

    November 18, 2009 @ 2:45 am

    Thanks for keeping us up to date, but do you have any news as to whether we should take the new vaccine for Swine flu? I am on avonex, and can’t decide what to do.

    Reply
    • 

      Geoff said

      November 19, 2009 @ 10:27 pm

      Janet,
      I take rebif and I just got my H1N1 and seasonal flu vaccines today. I based it on this info from the Canadian MS society:

      http://www.mssociety.ca/en/flu_h1n1_vacc.htm

      I got the version without adjuvant.

      Geoff

      Reply
34. 

    AJC said

    February 24, 2010 @ 7:28 am

    Hello All.

    Thanks for all your thoughtful comments and insights. Maybe you could share a few more?

    I was asked to do a “case study” on the MS market as part of a job interview. I am interested in your thoughts on the next 5 years.

    1. Are you eager to use the oral prods when they become available?
    2. Are you scared of the side effects [PML] with Tysabri?
    3. Are you particularly interested in any of the products in phase III?
    4. You are the MS experts. Any thoughts on living with MS now vs what it will be like in a few years?

    Thanks and Good Luck,
    Anxious Job Candidate

    Reply
35. 

    Sande H said

    May 7, 2010 @ 5:12 am

    I was dx with RRMS in 1999, started Avonex & doing pretty well. Earlier this year another dr put me on an oral steroid, Entocort – 3mg/day for a non-MS problem. WOW, my MS symptoms either went away or got so much better. I had none of the usual side effects ie: weight gain, insomnia, mood swings, etc. I do understand the problems associated with long term steroid use, bone loss, elevated blood sugar, etc but wonder if anyone might be looking into use of this steroid for MS. My dr said there is no data available.

    Reply
    • 

      Geoff said

      May 7, 2010 @ 6:57 am

      Sande,
      I’m glad you are getting such good results with a steroid. I looked around and didn’t see any evidence of MS trials for Entocort. People definitely do get symptom relief with steroids and there has even been some interest in using monthly doses of steroids to slow down the disease (not entocort). See here:

      http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2008000300013&lng=en&nrm=iso&tlng=en

      Reply
36. 

    Janet Summers-Tembeli said

    May 7, 2010 @ 9:49 am

    All MS sufferers, I was treated with cortisone tablets 10 in the am and 5 in PM
    and I must say the following:I quickly became diabetic with my sugar out of control, low enough to become comatose and in the same day high enough to die. Also from healthy bones to extreme osteoporosis which came suddenly and left me with a spine that is hollow, and is more of a life threat than MS. Also Cushings syndrome which my NEW Doc tells me will fully leave my body after 6-7 years. My veins all came to the surface and my skin became as thin as a butterfly wing, my gums and teeth suffered damage, I had recurring hemmorages in my eyes and am plagued by eye infections and urine infections. My body will never be the same but I am on interferon now for 4 years and avoid cortisone like the plague. My MS is under control, and I haven’t had a new lesion or lesion growth for 4 years. MS also requires drugs for panic, depression, anxiety and certainly ginko bilboa, flax seeds, magnesium help . My advice to anyone is NO CORTISONE for more than 3 days…IT WILL KILL YOU…and it is not the right treatment for MS, it is used
    to stop the lesions from intensifying after a relapse, and 3 days is enough!

    Reply
37. 

    Monika said

    August 30, 2010 @ 7:09 am

    hello sir,
    its really incredible that you have track of all the recent updates in Drug research. Sir I am not able to find out the fate of CRA-028129 (cathepsin S inhibitor) (Schering). Why it was all of a sudden stopped?

    Is there any other molecule of any company in Clinical Trials?
    Kindly let me know sir.

    Reply
    • 

      Geoff said

      August 31, 2010 @ 9:04 am

      Monika,
      I don’t really know what is going on with CRA-028129 as I think it was still in pre-clinical development last I heard. The most recent news I’ve seen is from a few years ago:

      Celera Genomics announced that CRA-028129 was in a phase 1 trial, but it has been purchased by Schering. I guess there is a connection between Bayer and Schering, and in a 20-F SEC report in 2007, Bayer had this to say about CRA-028129:

      “In June 2006, we acquired Celera Genomic’s cathepsin S inhibitor drug development program. These oral cathepsin S inhibitors are small molecules with an innovative mode-of-action that have potential in the treatment of auto-immune diseases like multiple sclerosis, Crohn’s, psoriasis and rheumatoid arthritis. We have exclusive rights worldwide. The technology is still in a pre-clinical stage.”

      Reply
38. 

    Tyler D said

    September 7, 2010 @ 11:14 am

    Hi there! I was diagnosed with MS (RR) about 4 months ago and have had one real bad episode that kicked my butt. I try my hardest to keep on top of all of the new drugs out there so I can talk to my Dr but I find it next to impossible. How up to date is this list? It looks like it’s from March of this year and from my research, a lot has changed since then. Are you planning on updating this anytime soon? It’s really awesome that you put this together, I have found it very useful. I am on Avonex and it is TERRIBLE! I’m a 31 year old male in good shape and I take the shot every Sunday night. It’s painful to administer and the side effect are horrible. Also, it makes me so weak I can barely function. I hope to find an oral med that works better without all these side effects so I can get back to exercise etc.
    Thanks again for this blog, very nicely done!

    Reply
    • 

      Geoff said

      September 7, 2010 @ 7:39 pm

      Tyler, I try to keep the list more or less up to date on an ongoing basis, but I go through things in detail only once or twice a year. I’m about due for a thorough update one day soon, maybe when work quiets down a little.

      I hope the avonex side effects wear off over time for you. Hopefully cladribine and fingolimod with both be approved by the end of the year to give you some options.

      Geoff

      Reply
      • 

        Janet said

        September 8, 2010 @ 12:47 am

        Hi, I have been on avonex for a few years now, with no episodes, and have regained some movement. The side effects, fever, muscle tension etc. have never subsided. I usually end up in bed for 24 hours. Have heard that avonex will be coming out with an oral dose taken everyday so maybe the side effects will be less, as the once weekly shot is really strong. Also sweating is a problem, only from the head but like I just took a shower, and usually on 3rd. day after shot night sweat.
39. 

    Janet said

    September 8, 2010 @ 12:48 am

    Swimming has had a wonderful result for me, I swim everyday for at least an hour, and can do movements in the water that are impossile otherwise.

    Reply
40. 

    Wil said

    February 8, 2011 @ 5:26 pm

    My daughter was diagnosed last week. I am thinking of buying a soft cell portable hyperbaric chamber. Is this helpful or dangerous treatment for MS?

    Reply
    • 

      Geoff said

      February 8, 2011 @ 7:10 pm

      Wil,
      I don’t think hyperbaric is likely to be either dangerous or helpful from what I know. Here are a couple of research abstracts on hyperbaric treatment of MS:

      http://www.ncbi.nlm.nih.gov/pubmed/20415839

      http://www.ncbi.nlm.nih.gov/pubmed/14974004

      I hope your daughter is doing well.

      Geoff

      Reply
41. 

    Mike said

    June 9, 2011 @ 9:27 am

    Hi Geoff- Really great website. Any new updates. Recently diagnosed and looking for some hope. Thanks so much.

    Mike

    Reply
42. 

    Patrick said

    June 17, 2011 @ 9:53 pm

    Hi,
    What is the deal with the stem cell treatments in Panama? Lots of people claiming it helped. Only negatives I saw was over their prices. Do you know of any documented health risks?
    Thanks,
    Patrick

    Reply
43. 

    Sam Jackson said

    September 1, 2011 @ 6:15 am

    This is a great resource – thank you for your hard work. Did I miss these compounds, or do they not fit in the remit?:

    SR1001 – Scripps Research Institute compound affecting Th17 cells
    http://www.ncbi.nlm.nih.gov/pubmed/21499262

    E2007 (parempanel) – Eisai – Not specifically for MS at the moment, but it is listed as one of their indications.

    Sam, MS Researcher

    Reply
    • 

      Geoff said

      September 1, 2011 @ 7:22 am

      Sam,

      Thanks for the information. In October 2006, I removed E2007 from the list, back when it was just posted at ThisIsMS.com, because I didn’t see any reference to MS. But now I will add it back on to the list. I’d be curious to know what was going on behind the scenes at Eisai that they were testing E2007 back in 2004-5, then stopped, then restarted. Or maybe it was just a website issue. On the Scripps compound, it appears to be pre-clinical, and I’ve stopped following pre-clinical compounds because there are such incredibly long odds against them ever becoming approved therapies.

      Thanks again for your feedback.

      Geoff

      Reply
44. 

    LuCi said

    December 12, 2011 @ 2:24 am

    Is Merck Serono’s Extended Release Formulation of IFNbeta-1a really the same as ARX 424? They’re listed separately on the company’s pipeline page.

    Reply
45. 

    Harri Liuksiala said

    January 17, 2012 @ 10:32 pm

    Karo Bio (Sweden) has plans for a treatment..familiar ?

    Reply
    • 

      Geoff said

      January 18, 2012 @ 8:20 am

      Harri, I don’t know anything about it, but it appears to be in the early stages still. Do you know when they hope to begin phase 1 trials?

      Reply
46. 

    Harri Liuksiala said

    January 21, 2012 @ 2:55 am

    Dear Geoff,
    Karo Bios aim is to repair and reconstruct myelin through ER-beta agonists, and they are looking for partner in bigger pharma, in negotiations with companies that are already active in MS area. So early but progressing. Hope my terminology is correct, no connoisseur in the field.

    Reply
47. 

    Blueyeguy said

    April 9, 2012 @ 9:13 pm

    Geoff, thanks for this wonderful blog! I’ve often referred others to here; you have the most comprehensive list by far.

    You may want to take a look at the Myelin Repair Foundation – myelin repair.org for inclusion on your company list.

    Thanks again.

    Reply
48. 

    alicia espino said

    April 19, 2012 @ 7:13 am

    i just found your blog thankyou
    how can i find out when they are starting trails this sound karo bios will start tx again

    Reply
    • 

      Geoff said

      April 19, 2012 @ 12:39 pm

      I’m not sure if there is more up to date information about Karo Bio, but their website shows that their multiple sclerosis drug is still in the “discovery” phase and hasn’t even moved to “pre-clinical” yet (see: http://www.karobio.com/file/productportfolio-en-120403.png). Looks to me like they are still years from a clinical trial.

      Reply
      • 

        alicia espino said

        April 20, 2012 @ 5:13 am

        thank you so much for you quick response we are looking for something i guess you begin wishful thinking di
49. 

    Harri said

    April 19, 2012 @ 12:57 pm

    Hi, yes Karo Bio is looking for a bigger company to co-operate with. The other nordic project Laquinimod seems to be developing faster…

    Reply
50. 

    rosemarie said

    April 30, 2012 @ 12:07 pm

    I would lie to know if anyone has info on masitinib? I would also like to know about amprya I know that it is supposed to improve walking,can anyone tell me if they have used this product.

    Reply
51. 

    Rikker said

    June 25, 2012 @ 8:59 am

    Hi there,

    Thank you for the list that you have provided and the continued upkeep of your MS pipeline blog. It’s interesting to see what’s out there and the potential of cures that gives many of us hope.

    In regards to line 31. Mesenchymal Stem Cells (4 trials) in phase II

    Do you happen to know the names of the companies that are conducting/sponsoring those four phase II trials and where the trials are taking place?

    Regards,

    Rikker

    Reply
52. 

    mohammed said

    July 5, 2012 @ 9:03 am

    Dear All:
    My wife planning to start using BETAFERON and NU100 for MS treatment in a trail clinic- Ukraine. any advice regard this type of medication will be great help to us.

    Regards
    Momo

    Reply
53. 

    Priyadarshini Soman said

    July 25, 2012 @ 1:28 am

    Huzzah! New update! You’ve obviously been working on your writing skills. Good work 🙂 Thank you so much for the cleverness of well – you!

    Reply
54. 

    Laura K said

    August 14, 2012 @ 3:21 pm

    This takes a tremendous amount of talent, determination and dedication – thanks for putting all three together in this blog. This is extremely useful. – Laura

    Reply
55. 

    justincamp said

    September 22, 2012 @ 3:32 am

    Living with multiple sclerosis require solid stamina.

    Reply
56. 

    KinetaKen said

    September 26, 2012 @ 2:44 pm

    Geoff,

    Congratulations on a great blog! It appears you’re doing your homework and keeping your readers apprised of the very latest.

    Your comments about Kineta’s ShK-186 drug candidate intrigued me. I work for the company and would be pleased to respond to anyone’s questions regarding our first-in-class drug which recently entered first-in-human trials.

    Reply
57. 

    Kolagen Naturalny said

    October 17, 2012 @ 3:26 pm

    Excellent article. Keep writing such kind of info on your
    site. Im really impressed by it.
    Hi there, You have done an excellent job. I will certainly digg it
    and personally suggest to my friends. I’m confident they will be benefited from this web site.

    Reply
58. 

    "Absalom" said

    March 8, 2013 @ 7:24 pm

    I’m extremely impressed with your writing skills and also with the layout on your weblog. Is this a paid theme or did you customize it yourself? Either way keep up the excellent quality writing, it’s
    rare to see a great blog like this one these days.

    Reply
59. 

    DeanaGullicksen said

    March 19, 2013 @ 12:39 pm

    I have had this disease since 1998 when I lived in Atlanta G.A. Then I moved to Wilmington N.C. . And have been on several alot of these drugs ,Have had some exacerbations and hospital visits for that fact . And moved to Maine and was last on Tysabri for quite sometime . And now I’ve just moved back to M.A. and am currently taking steroids before I get on BG 12 . And my very first thing I said when I was diagnosed was I don’t. Want to go.on a wheelchair . So I walk with a Cain and when I am gonna fall I hop Which works for me m Not saying that I have never fallen of course . But I have to try to keep up a positive attitude and never think I CAN’T ! And I do have RELAPSING/REMITTING =/ But I eat right is KEY # 1 . And am in hopes of the CURE to be found for this MSBS as I refer to it as . I think that everyone gets something along the way . And if you don’t. ever than GOD BLESS YOU ! But those of you that do or may PLEASE LOOK INTO YOUR DIET and make the appropriate changes =) Good Luck to all of you and the next “road you travel down ” Be at peace with yourself and GOD BLESS YOU ;-):|

    Reply
    • 

      alicia espino said

      March 20, 2013 @ 8:46 am

      hi

      my daughter has had it since 2003 and tried beta serum didnot work for he r at all it was awful but we were considering tasabri what is your learned opinion we also thought bg12 we are also praying one of this researcher stumbles on a stopper if not a cure
      all good things to go your way
      ps thanks for sharing
      🙂

      Reply
60. 

    Marie Wesselhoft said

    April 28, 2013 @ 6:53 am

    thanks so much for this comprehensice list. I am a founder of a small company working on simple blood test for monitering disease activity in a patient with MS. Our goal is that these tests would be used to help the patient and the neurologist understand if a patient is responding to the drug treatment they are taking. In MS there is no blood test avaialble to do this. We would like to change that!

    I was building a list to pipeline drugs so that we could reach out to these studies and see if they would like to add our blood test to their study. So, when I found your list…..I was elated.

    My name is Marie Wesselhoft at mwesselhoft@msdx.co. Feel free to send me an email if you would like.

    Keep up the good work.

    Reply
61. 

    ośrodek leczenia uzależnień wrocław said

    May 26, 2013 @ 12:03 am

    With havin so much content do you ever run into any problems of
    plagorism or copyright violation? My blog has a lot of unique content I’ve either authored myself or outsourced but it appears a lot of it is popping it up all over the internet without my authorization. Do you know any techniques to help stop content from being ripped off? I’d genuinely appreciate it.

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    Reply
62. 

    Fischölkapseln said

    June 11, 2013 @ 11:49 am

    Spot on with this write-up, I seriously believe this site needs a lot more attention.
    I’ll probably be back again to see more, thanks for the information!

    Reply
63. 

    soul said

    June 27, 2013 @ 4:33 pm

    MS R-R dx 89 I quit Rebif, after 18 + years, I was a trial patient. Now just about a year out from my last shot.I do worry, Docs will not even look at LDN, I guess I am pretty much washed out of other therapies.
    Any Ideas
    soul

    Reply
    • 

      Geoff said

      June 28, 2013 @ 7:48 am

      Wow, 18+ years! I’m on Rebif too, but have only been taking it for 9+ years. Have you tried to get Tecfidera? My neuro seems pretty keen on it. Through most of the clinical trial process it was called BG-12. It is a pill, has reasonable side effects, and appears to be more efficacious than any other approved therapy.

      Reply
      • 

        soul said

        June 28, 2013 @ 9:08 am

        I am not to comfortable with Tec. I have yet to see good research I guess I waiting for the “other shoe to drop” and at 55. Grand a year, I question the drug company’s money grab on this drug.
        And do not tell me R&D because its been around for years
64. 

    Sandeep said

    July 16, 2013 @ 10:16 pm

    This list is grossly misleading, erroneous and un-updated (since 2005) specifically the preclinical section (I have checked that personally). A large no. of candidate molecules listed here had already been withdrawn as early as 2006. Many companies are defunct and molecules have been discarded. Age old molecules have been listed here that are lost now from the MS segment.
    Example: AT-008 (Androclus)- Company defunct
    AZD 8797 (AstraZeneca)-Discarded in 2006
    A lot more….

    Reply
    • 

      Geoff said

      July 17, 2013 @ 7:33 am

      You are right. I was investigating preclinical substances back in 2004-2006, but stopped since they are such a long shot for eventual approval. I thought I’d include the info on the list, but I think I left it too long, so will delete now.

      Reply
      • 

        Sandeep said

        July 17, 2013 @ 9:59 pm

        But you did a great job, Geoff, anyways
65. 

    soul said

    October 5, 2013 @ 5:50 am

    So 18 years on Rebif, I am done with the DMD’s anybody have an idea for a natural remedies ?
    soul

    Reply
66. 

    soul said

    November 20, 2013 @ 5:44 am

    Off label Therapies.
    I have been using Cesamit for a year now. It’s the best year I have had since my MS dx in 98 . People may want to look into this synthetic THC
    I don’t feel drug sick all the time less pain, & more energy. Thanks Geoff for a very informative blog.
    soul

    Reply
67. 

    grace said

    November 29, 2013 @ 4:54 am

    Off label Therapies.
    I have been using Cesamit for a year now. It’s the best year I have had since my MS dx in 89 . People may want to look into this synthetic THC
    I don’t feel drug sick all the time less pain, & more energy. Thanks Geoff for a very informative blog.
    soul

    Reply
68. 

    Rosanna TRaverso said

    December 8, 2013 @ 12:24 pm

    What you think of anti lingo and stem cell. I am gong to see a dr in phx dr malan he will take my fat seperate the cells and inject back into me. His fee is 12000 what you think? I am also starting the clinical trial for anti lingo in mid jan. I have Pam’s and I am in lots of pain expacialy my legs, I am desperate for relief from this pain that is present 24 hrs a day 7 day a week

    Reply

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