This list gives a bit more detail about the phase 3 trials in progress. Typically, if there is an announcement of a drug successfully completing a trial, I will move it to the next stage before I see a press release or report saying that a new trial is starting. I assume it will move to the next stage. The only exception is for small (20-100 participants) phase 2 trials, as drugs don’t seem to move to phase 3 until they have completed a placebo-controlled phase 2 trial with well over 100 participants.
[updated April 6, 2013]
Phase III Trials
1. Autologous hematopoietic stem cell transplantation (aka Multiple Sclerosis International Stem Cell Transplant Trial)
http://www.clinicaltrials.gov/ct2/show/NCT00273364
2. Campath (aka alemtuzumab or Lemtrada) (Genzyme)
http://www.genzyme.com/research/pipeline/pipe_home.asp
http://www.clinicaltrials.gov/ct2/show/NCT00530348
http://www.clinicaltrials.gov/ct2/show/NCT00548405
http://www.clinicaltrials.gov/ct2/show/NCT00930553
http://www.clinicaltrials.gov/ct2/show/NCT01307332
http://www.clinicaltrials.gov/ct2/show/NCT01333358
http://www.clinicaltrials.gov/ct2/show/NCT01395316
3. Daclizumab (aka Zenapax) (Abbott, Biogen-Idec)
http://www.abbott.com/news-media/press-releases/2011-oct22.htm
http://www.biogenidec.com/research_product_pipeline.aspx?ID=5778
http://www.clinicaltrials.gov/ct2/show/NCT01064401
http://www.clinicaltrials.gov/ct/show/NCT00390221
http://www.clinicaltrials.gov/ct2/show/NCT01051349
http://www.clinicaltrials.gov/ct2/show/NCT00870740
http://www.clinicaltrials.gov/ct2/show/NCT01462318
4. Gilenya (aka fingolimod or FTY720) (PPMS) (Novartis)
http://www.clinicaltrials.gov/ct2/show/NCT00731692
5. Interferon beta 1a – PEGylated (BIIB017) (bi-weekly or monthly injection) (Biogen Idec)
http://www.clinicaltrials.gov/ct2/show/NCT00906399
http://seekingalpha.com/article/119054-biogen-idec-q4-2008-earnings-call-transcript?page=4
6. Laquinimod (aka ABR-215062) (Teva)
http://www.tevapharm.com/en-US/Media/News/Pages/2011/1618694.aspx
http://www.clinicaltrials.gov/ct2/show/NCT00509145
http://www.clinicaltrials.gov/ct2/show/NCT00605215
http://www.clinicaltrials.gov/ct2/show/NCT00988052
http://www.clinicaltrials.gov/ct2/show/NCT01047319
7. Masitinib (SPMS and PPMS) (aka Kinavet or AB1010) (AB Science)
http://clinicaltrials.gov/ct2/show/NCT01433497
http://www.abstracts2view.com/aan2009seattle/view.php?nu=AAN09L_P06.130
8. Minocycline (MS Society of Canada, MS Scientific Research Foundation)
http://www.clinicaltrials.gov/ct2/show/NCT00666887
http://www.msanswers.ca/QuestionView.aspx?L=2&QID=636
9. Ocrelizumab (R1594) (trials for PPMS and RRMS) (Genentech, Roche, Biogen)
http://www.roche.com/research_and_development/pipeline/roche_pharma_pipeline.htm
http://www.clinicaltrials.gov/ct2/show/NCT01194570
http://www.clinicaltrials.gov/ct2/show/NCT01412333
http://www.clinicaltrials.gov/ct2/show/NCT00676715
http://www.clinicaltrials.gov/ct2/show/NCT01247324
10. Progestin and Estradiol (Hospices Civils de Lyon)
http://www.clinicaltrials.gov/ct/show/NCT00127075
11. Revimmune (aka Cyrevia OR high-dose cyclophosphamide) (Accentia Biopharmaceuticals)
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